Drug delivery in cochlear implantation

Intra-cochlear fibrous tissue formation around the electrode following cochlear implantation affects impedance as well explantation during reimplantation surgeries. Applying corticosteroids in is one way of minimizing intra-cochlear electrode. It were J. Kiefer, C. von Ilberg, and W. Gstöttner who proposed first idea on drug delivery application to MED-EL year 2000. During twenty years translational research efforts at collaboration with several clinics institutions from across world, preclinical safety efficacy performed leading final formulation design. In parallel eluting CI development, also invested into developing tools enabling pharmaceutical agents surgeon’s choice inside cochlea. The inner ear catheter designed administer substances cochlea was CE marked 2020. A feasibility study human subjects featuring dexamethasone-eluting array started June This article covers milestones towards that took place association MED-EL.